Postmenopausal osteoporosis management

A review of the evidence to inform the development of quality indicators

by Annalijn Conklin, Ohid Yaqub, Claire Celia, Ellen Nolte

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This report aims to inform the development of quality indicators for postmenopausal osteoporosis management through (a) assessing the evidence for screening and diagnosis of osteoporosis and related risk factors, and for prevention and treatment of osteoporosis and osteoporosis-related fractures; (b) describing current practice for managing postmenopausal osteoporosis in Europe; and (c) highlighting existing gaps in the evidence base and management practices in Europe. Analyses involved a comprehensive review of reviews regarding the screening and diagnosis of osteoporosis and related risk factors and the prevention and treatment of osteoporosis and osteoporosis-related fractures. While this identified a well developed evidence base on the effects of selected treatments on clinical outcomes of postmenopausal osteoporosis and associated fractures, and on the usefulness of selected simple risk factor assessment tools to identify postmenopausal women who would benefit from further diagnostic assessment, uncertainties remain regarding for example the optimal use of pharmacological interventions for preventive purposes and the effectiveness of population-based screening. We also carried out case study reviews of current practices for managing postmenopausal osteoporosis in England, France, Germany and Spain. We identify a need for the establishment of routine monitoring systems to enable better understanding of contemporary patterns and trends and identify care gaps in the management of postmenopausal osteoporosis and associated fractures. Such analyses are crucial to inform targeted strategies and policies to effectively address the burden of osteoporosis and associated fractures, which is sizable and set to increase across Europe. We set out considerations as a starting point for the further development of quality measures for postmenopausal osteoporosis in Europe.

Table of Contents

  • Chapter One

    Introduction

  • Chapter Two

    The diagnosis, prevention and treatment of postmenopausal osteoporosis

  • Chapter Three

    Managing postmenopausal osteoporosis in Europe

  • Chapter Four

    Informing the development of quality indicators for the management of postmenopausal osteoporosis

  • Appendix A

    Overview of guidelines in place in four countries

  • Appendix B

    Interview topic guide

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The research described in this document was prepared for Amgen and conducted by RAND Europe.

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