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The cover story spotlights RAND research on America's fentanyl crisis — a poisoning outbreak unlike previous drug epidemics that will require innovative responses and significant resources to confront. A second feature explores new approaches to clinical guideline development — ones that consider the experiences of not only health care practitioners but also patients and caregivers. In this issue's Commentary column, terrorism expert Colin Clarke reflects on the threat of white supremacists in the United States. And the Giving column highlights Ann Korologos, whose recent $2 million estate gift has established the Ann Korologos Impact Award Endowment at RAND.

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