Mental Health Retrosight
Oct 28, 2013
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This study examines the impacts arising from neuroscience and mental health research going back 20-25 years, and identifies attributes of the research, researchers or research setting that are associated with translation into patient benefit, in the particular case of schizophrenia.
This report presents the full set of forward-tracing case studies.
The study combined two methods: forward-tracing case studies to examine where scientific advances of 20 years ago have led to impact today; and backward-tracing perspectives to identify the research antecedents of today's interventions in schizophrenia. These research and impact trails are followed principally in Canada, the UK and the USA. The headline findings are as follows:
Changes in striatal dopamine neurotransmission assessed with microdialysis following recovery from a bilateral 6-OHDA lesion: variation as a function of lesion size
Synaptic modulation by dopamine of calcium currents in rat pars intermedia
Differential distribution of GABAA receptor mRNAs in bovine cerebellum
Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding
PET scanning and schizophrenia
Organisation of dopamine D1 and D2 receptors in human striatum: receptor autoradiographic studies in Huntingdon's disease and schizophrenia
Auditory P300 in borderline personality disorder and schizophrenia
Elevation of human brain D2 dopamine receptors in schizophrenia
Expressed emotion research in London, UK, Chandigarh, India and Aarhus, Denmark
Northwick park study of outcomes following and characteristics prior to first schizophrenic episodes
Low frontal glucose utilization in chronic schizophrenia: a replication study
Using childhood home movies of adult schizophrenia patients to investigate the development of physical and behavioural abnormalities
Verapamil in the treatment of chronic schizophrenia
The effects of neuroleptics on lateralisation in schizophrenic patients
Specific and non-specific effects of educational intervention
Psychiatric morbidity of a long stay hospital population with chronic schizophrenia and implications for future community care
Randomised controlled trial of an inpatient family intervention for schizophrenia and affective disorders: the importance of gender in outcome and treatment response
Treatment Strategies in Schizophrenia (TSS)
The project described in this report was supported in Canada by the Graham Boeckh Foundation, Alberta Innovates Health Solutions, and the Canadian Institutes of Health Research; in the UK by the National Institute for Health Research; and in the USA by the National Institute of Mental Health. The research was conducted by RAND Europe.
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