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This intervention manual for the Collaboration Leading to Addiction Treatment and Recovery from Other Stresses (CLARO) research study intervention advances a collaborative care model of primary care–centered treatment for patients who have co-occurring opioid use disorder with major depressive disorder and/or post-traumatic stress disorder. Through this intervention, clinical members of the collaborative care team — primary care providers, behavioral health providers, and behavioral health consultants — will work closely with a care coordinator to manage the patient's overall care and ensure that they get high-quality, effective, and patient-centered care. By offering concurrent treatment for both opioid use disorder and mental illness, the CLARO intervention aims to improve patient outcomes for this vulnerable and underserved population. CLARO has been implemented at clinics in New Mexico and health centers in California.

The introduction provides a general overview of the CLARO study; the remainder of the manual presents the step-by-step instructional format for members of the care team involved in the CLARO intervention. A companion CLARO implementation manual describes the implementation process and the supports used to bring the CLARO intervention to primary care clinics.

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This research was funded by a grant from the National Institute of Mental Health and carried out within the Access and Delivery Program in RAND Health Care.

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