More resilient funding for cancer research in the UK

An option appraisal

Hampton Toole, Jon Sussex, Mehdi Shiva, Sorana Bucseneanu, Mark Cabling, Priyanka Cardoz, Shaun Leamon

ResearchPublished Jul 28, 2025

Non-commercial cancer research in the UK relies heavily on the charity sector for funding, which in turn is substantially reliant on income from donations. This income fell as a result of the Covid-19 pandemic. The status quo creates challenges for predictably funding cancer research in the UK. The purpose of this study was to explore options for how cancer research funding in the UK could be made more resilient. To conduct this research, RAND Europe deployed an approach in line with HM Treasury Green Book option appraisal guidance and based on multi-criteria decision analysis (MCDA). Drawing on desk research, stakeholder interviews and workshops, and in consultation with Cancer Research UK, the research team compiled and appraised a long-list of funding options, including more government investment in cancer research via public agencies; direct government funding to cancer research charities; an endowment fund; government-issued ‘cancer research’ bonds/gilts; megafunds; crowdfunding; venture philanthropy; outcome partnerships/social impact bonds; hypothecated tax; and public-private partnerships (including matched funding). From this long-list, the research team identified an endowment fund as the preferred option for funding non-commercial cancer research in the UK. Researchers then explored the wider ramifications of an endowment fund, including who might be expected to fund it and how it may interact with the wider cancer and medical research funding landscape.

Key Takeaways

Many possible funding models

  • There are many possible models for funding non-commercial cancer and/or general medical research, including government-issued ‘cancer research’ or ‘medical research’ bonds/gilts, megafunds, venture philanthropy, outcome partnerships/social impact bonds, and hypothecated tax.

An endowment offers greater predictability

  • An endowment fund was identified in discussion with Cancer Research UK as the preferred new option for funding non-commercial cancer research in the UK, drawing on UK and international examples such as the Wellcome Trust, Nesta and the Australian Medical Research Future Fund (MRFF).

Various sources of funds for an endowment

  • Funds for the endowment are likely to come from a mixture of private, and possibly public sector, sources. The fund could be increased over time.

Topics

Document Details

  • Publisher: RAND Corporation
  • Availability: Web-Only
  • Year: 2025
  • Pages: 55
  • DOI: https://doi.org/10.7249/RRA3895-1
  • Document Number: RR-A3895-1

Citation

Chicago Manual of Style

Toole, Hampton, Jon Sussex, Mehdi Shiva, Sorana Bucseneanu, Mark Cabling, Priyanka Cardoz, and Shaun Leamon, More resilient funding for cancer research in the UK: An option appraisal. Santa Monica, CA: RAND Corporation, 2025. https://www.rand.org/pubs/research_reports/RRA3895-1.html.
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